A hilariously absurd story, Arsenic and Old Lace tells of a newlywed dramatic critic (Cary Grant) in the big city who lives with two aunts (Josephine Hull and Jean Adair) and an uncle (John Alexander).

Uncle Teddy is bonkers and thinks hes Teddy Roosevelt. The aunts think Teddy is the only one thats gone mad but, in fact, they have lost the plot themselves... for they have been murdering lonely elderly gentlemen in their own home and burying them in the cellar.

When the nephew finds out, he goes a little weird himself in his attempt to figure out what to do about it.

Everything gets worse when the long, lost delinquent brother (Raymond Massey) returns home after a prison escape and is looking for a place to live and to bury his most recent victim.